tPEMF® has been shown to have positive effects on both acute and chronic inflammation. Assisi signals virtually eliminate pain and significantly reduce swelling in rigorous laboratory and clinical studies.1 These results are comparable or superior to NSAIDs, without the potential for side effects.2

Assisi helps your patient heal faster by accelerating the natural anti-inflammatory cascade – non-invasively and without drugs. Assisi’s technology is proven in laboratory experiments with results published in peer-reviewed journals with demonstrated effect on the known biochemical and cellular mechanisms of action related to inflammation.

In veterinary medicine, Assisi devices have been used to treat arthritis, tendinitis, laminitis and other known inflammatory conditions.

1Johnson MT, Ramanathan M, Owegi R, Pilla AA. 2008. Modulation of carrageenan-induced paw edema and hyperalgesia in the rat with pulsed magnetic field therapy. Proceedings, 30th Annual Meeting, Bioelectromagnetics Society, Frederick, MD, June 2008, p. 156.
2al-Swayeh OA, Clifford RH, del Soldato P, Moore PK. 2000. A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin. Br J Pharmacol. 129:343-50.

Post-Surgical Healing

Using the Assisi products immediately after a surgical procedure and in the days after surgery enhances healing by accelerating the reduction of swelling and pain. The tPEMF® system can manage post-surgical inflammation as well as wound healing, enabling rehabilitation to begin more quickly and safely. The device is simple to use. It may be placed directly over any wound dressing and non-metallic splints. A single manual treatment lasts only 15 minutes. Similar technology has been cleared by the FDA specifically for the treatment of post-operative pain and edema in humans.

Assisi products can be supplied to treat post-procedural sites with a pre-programmed treatment regimen, which improves compliance and thereby enhances outcomes.

Published studies have shown that tPEMF:

  • Accelerates surgical wound healing by up to 58%1
  • Accelerates tendon repair by up to 69%2
  • Accelerates the growth of new blood vessels that support tissue healing 3,4

1Strauch B, Patel MK, Rosen DJ, Mahadevia S, Brindzei N, Pilla AA. 2006. Pulsed magnetic field therapy increases tensile strength in a rat Achilles’ tendon repair model. Journal of Hand Surgery. 31:1131-1135
2Strauch B, Patel MK, Navarro A, Berdischevsky M, Pilla AA. 2007. Pulsed magnetic fields accelerate wound repair in a cutaneous wound model in the rat. Plast Reconstr Surg 120:425-430
3Roland D, Ferder M, Kothuru R, Faierman T, Strauch B. 2000. Effects of pulsed magnetic energy on a microsurgically transferred vessel. Plast Reconstr Surg 105:1371-1374.
4Weber RV, Navarro A, Wu JK, Yu HL, Strauch B. 2004. Pulsed magnetic fields applied to a transferred arterial loop support the rat groin composite flap. Plast Reconstr Surg 114:1185-1189

Wound Healing

The Assisi technology has been demonstrated to improve wound healing 58% faster than wounds which have not received PEMF Therapy.1 There are many reports of the use of electrical currents to enhance chronic wound healing, with varied, and sometimes equivocal, results.2 Assisi tPEMF® technology provides you with a method of safely and non-invasively inducing targeted electrical currents to enhance wound repair, without the necessity of direct skin contact.3 The tPEMF therapy may be used to enhance wound repair in virtually all post-surgical cases. There have been no reports of the use of electrical current applied with skin electrodes to enhance acute wound repair, primarily because patient morbidity would increase rather than decrease.

In tendon healing, not all PEMF signals are equal; Assisi’s targeted PEMF signals make the difference.

1Strauch B, Patel MK, Navarro A, Berdischevsky M, Pilla AA. 2007. Pulsed magnetic fields accelerate wound repair in a cutaneous wound model in the rat. Plast Reconstr Surg 120:425-430.
2Ramadan A, Elsaidy M, Zyada R. 2008. Effect of low-intensity direct current on the healing of chronic wounds: a literature review. J Wound Care. 17:292-6.
3Strauch B, Herman C, Dabb R, Ignarro LJ, Pilla AAv. 2009. Evidence-based use of pulsed electromagnetic field therapy in clinical plastic surgery. Aesthet Surgery Journal. 29:135-43.

Assisi targeted PEMF (tPEMF)® technology summary

Assisi’s targeted pulsed electromagnetic field technologies emerge out of a century-long evolution of using electrical currents to improve health and healing. Pulsed electromagnetic fields are simply delivery systems for inducing electrical current. Pulsing an electromagnetic field near a conductor (such as tissue) will induce current flow in the conductor.

This simple law from physics allows currents to be induced in tissue from outside the body, without anything touching the skin. Magnetic fields penetrate through bandages, casts, fur, hair etc. The simple induction of electrical current in tissue is the functional therapeutic component of Assisi’s tPEMF® technology.

Historically, PEMF technologies were generally large, AC-powered devices that produced a substantial magnetic field. Even today, manufacturers of some PEMF devices describe them as “powerful” or “more powerful”. During much of this period of development, PEMF devices did not have a specific or known biological target. Developing medical applications of the technology was largely driven by trial and error based on unproven assumptions that greater power was likely to produce better outcomes.

We now know those assumptions to be incorrect. By the 1970s, researchers and clinicians had developed relatively low-powered PEMF devices – bone growth stimulators (BGS) – to heal recalcitrant fractures. Although demonstrated to be effective at fracture repair at low power, the specific mechanism of action remained elusive.

Arthur A. Pilla, one of the inventors of BGS technology and a professor of Biomedical Engineering at Columbia University, was also the original developer of Assisi’s targeted PEMF products. He focused significant time and resources on researching mechanisms of action for PEMF and developing PEMF signals. Among the potential targets proposed in the literature, research suggested that calcium binding was a likely candidate, in particular, the binding of calcium (Ca) to calmodulin (CaM). This particular complex is a voltage-dependent process responsible for a number of potentially therapeutic biological cascades, most importantly the natural anti-inflammatory cascade.

Learn more about the science behind the technology here.

The Ca/CaM anti-inflammatory cascade is well described. The initial binding of four calcium ions to calmodulin produces a conformational change in CaM, which, in turn, then binds to the constitutive nitric oxide syntheses (both endothelial – eNOS and neuronal – nNOS), which virtually immediately (within seconds) leads to the production of nitric oxide (NO), a principal anti-inflammatory molecule. Nitric oxide reduces pain, improves blood flow and reduces edema. It further triggers downstream effects, including the production of cGMP, the ‘energy’ molecule that then drives growth factor production, which, in turn, support new blood vessel formation, tissue regeneration and then, ultimately, to tissue remodeling.

What this means is that Assisi can bring the most effective targeted PEMF technology to veterinary medicine in small, lightweight and disposable configurations whose effectiveness is supported by a substantial and growing body of basic science and clinical research.